Paracetamol Tablets 500mg

Analgesic, Anti-Inflammatory & Anti-Pyretic · Film-Coated Tablets · 500mg

Trade Information

Minimum Order Qty	10,000 tablets
Capacity	100 Million Tablets per month
Strength	500mg
Private Labelling	Custom branding, artwork & market-specific labelling
Lead Time	45–60 days from order confirmation
Payment Terms	LC at sight, TT (advance / against documents)
Shipping	FOB / CIF to major international ports including Mombasa, Dar es Salaam, Lagos, Durban, Manila, Phnom Penh
Pharmacopoeia	BP, USP, IP compliant

Packing Options

Blister (Alu-Alu / Alu-PVC)
Strip pack
Bottle pack (HDPE)
Hospital bulk pack
Shrink wrap
Custom packing as per buyer requirement

Regulatory & Quality

Registration Status	Registered in multiple African, Asian, CIS, and Latin American markets. Dossier available for new market registration.
Regulatory Dossiers	CTD / ACTD format dossiers available for submission to national drug authorities.
Stability Data	Zone IVa & IVb stability data available (tropical climate conditions, 30°C/65% RH & 30°C/75% RH)
WHO Prequalification	WHO-GMP Certified

Product Details

Composition	Paracetamol (Acetaminophen)
Dosage Form	Film-Coated Tablets
Pack Size	10x10, 10x12, Bottle of 100/500/1000 / Custom packing available
Storage	Store below 30°C in a dry place, protected from light
Shelf Life	36 months from date of manufacture

Description

Paracetamol (Acetaminophen) is the world's most widely used analgesic and antipyretic. It is a first-line treatment for mild to moderate pain and fever, recommended by the WHO and included in the WHO Model List of Essential Medicines.

BioGalen manufactures Paracetamol Tablets 500mg in high volumes for domestic and export markets. Our tablets are manufactured under strict GMP conditions with consistent quality, making them suitable for government tenders, institutional procurement, and private sector distribution.

Paracetamol 500mg is one of the highest-volume pharmaceutical products in Africa, Asia, and Latin America, consumed across all age groups for everyday pain and fever management.

Mechanism of Action

Paracetamol's precise mechanism of action is not fully understood, but it is believed to primarily inhibit cyclooxygenase (COX) enzymes in the central nervous system rather than at peripheral inflammation sites. This central COX inhibition reduces prostaglandin E2 (PGE2) synthesis in the hypothalamus, lowering the body's temperature set point to produce its antipyretic effect. Its analgesic action may also involve activation of descending serotonergic pain inhibition pathways and interaction with the endocannabinoid system via its metabolite AM404. Unlike NSAIDs, Paracetamol has minimal anti-inflammatory activity and does not inhibit platelet aggregation, making it the preferred first-line analgesic for patients who cannot tolerate NSAIDs — including those with peptic ulcers, asthma, or bleeding disorders.

Indications

Mild to moderate pain (headache, toothache, backache)
Fever and flu symptoms
Post-vaccination fever
Musculoskeletal pain
Dysmenorrhoea (menstrual pain)
Post-operative pain (as adjunct therapy)

Available Variants

Paracetamol Tablets 500mg
Paracetamol Pediatric Oral Suspension
Paracetamol Infusion 1000mg
Paracetamol Infusion 1000mg (Glass Bottle)
Paracetamol 500mg, Chlorphenamine Maleate 2mg, Phenylephrine Hydrochloride 10mg & Caffeine 30mg Tablets
Ibuprofen 200mg & Paracetamol 500mg Tablets
Ibuprofen 400mg & Paracetamol 325mg Tablets
Diclofenac Sodium 50mg & Paracetamol 325mg Tablets
Diclofenac Sodium 50mg & Paracetamol 500mg Tablets

Frequently Asked Questions

Why is Paracetamol 500mg such a high-volume product for export markets?

Paracetamol 500mg is the single most consumed pharmaceutical product in Africa, Asia, and Latin America. It is used by all age groups for everyday fever and pain relief, is included in every national essential medicines list, and is a mandatory item in government health facility stock lists. For distributors, it offers consistent high-volume demand and is often the entry product for new market penetration.

What is the difference between Paracetamol and Ibuprofen for procurement?

Both are essential analgesics but serve different clinical needs. Paracetamol is the first-line choice for fever and mild pain, safe in pregnancy and for patients with stomach ulcers. Ibuprofen adds anti-inflammatory action for musculoskeletal conditions but carries GI risks. Most distributors and health systems procure both as they are complementary, not interchangeable.

What are the available combination products with Paracetamol?

BioGalen manufactures several Paracetamol combinations: Paracetamol + Ibuprofen, Paracetamol + Diclofenac, Paracetamol + Chlorphenamine + Phenylephrine + Caffeine (cold & flu), and Paracetamol Infusion 1000mg for hospital use. All combinations are available for private labelling.

What pack sizes are suitable for institutional and retail markets?

For institutional/hospital procurement, we offer 10x10 blister packs, bottles of 500 and 1000 tablets, and shrink-wrapped hospital bulk packs. For retail pharmacy, 10x10 and 10x12 blister strips and bottles of 100 are the most popular configurations. All packing can be customised to meet your market requirements.

Interested in Paracetamol Tablets 500mg?

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